• Ms. Kritika Baghela
• Mrs. Raksha Goswami
• Dr. Neetesh Kumar Jain

Aim of the present investigation was to develop an animal model mimicking human type 2 diabetes. High fat fed wistar rats after 28 days became obese and the blood glucose level reached 110 mg/dl. In this animal model obesity causes the border case exerting stress on beta cells to produce compensatory insulin. The stress, damaged the beta cells of islets of Langerhans- resulting hyperglycemia, thus leading to type 2 diabetes. The present work was to evaluate the therapeutic efficacy of T. cordifolia stem extract on type 1 and 2 diabetes induced animal model wistar rat various biochemical parameters investigated include blood glucose, after treatment with T. cordifolia stem extract with 150 and 250 mg/kg/day to diabetic group elevated levels were restored to control group level. Whereas glucose level decreased in diabetic group to that of control group of for treatment with T. cordifolia stem extract. The studies on the islets of Langerhans suggest that the plant extract treatment to diabetic group (150 and 250 mg/kg/day) to type1 and 2 diabetic rats resulted in the recovery of damaged islets and restoring the beta cell number, hence enhanced the insulin secretion, thus establishing the homeostasis of blood glucose The plant extract of T. cordifolia stem extract has improved the damaged Langerhans and enhanced insulin secretion of beta cells in type 1 and 2 diabetes. Therefore the plant extract of T. cordifolia has a therapeutic efficacy in alleviating type 1 and 2 diabetes but type 2 diabetes is totally invisible.

Diabetes, Insulin, Extract, Animal model, Obese, etc.

"Biological Evaluation of Plant Extract of Tinospora cardifolia in Diabetes Mellitus in the Animal Model", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 3, page no.d254-d261, March-2022, Available :http://www.jetir.org/papers/JETIR2203333.pdf

"Biological Evaluation of Plant Extract of Tinospora cardifolia in Diabetes Mellitus in the Animal Model", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 3, page no. ppd254-d261, March-2022, Available at : http://www.jetir.org/papers/JETIR2203333.pdf