• Ms. Mayuri S. Bhadalekar
• Mr. S. S. Shelake
• Mrs A. S. Pandav
• Mr. P. D. Chougule
• Ms M. V. Bhosale , Mrs P. B. Sutar, Dr. N. B. Chougule

Nano-emulsion is a relatively new and fascinating field of research that aims to take advantage of appealing qualities of components to increase oral administration, such as cinnamon oil's usage in diabetic disease management. The Self-Nano Emulsifying Drug Delivery System (SNEDDS) offers a lot of promise for enhancing the solubility and bioavailability of medicines that are poorly soluble. So an effort was made to increase the solubility, dissolving rate, and bioavailability of cinnamon oil utilizing SNEDDS. Cinnamon oil's solubility was tested in a variety of vehicles, including oils, surfactants, and co-surfactants. Based on the solubility, a pseudo-ternary phase diagram was created to determine the most effective selfemulsification zone. For the manufacture of SNEDDS, oleic acid (oil), Tween 80 (surfactant), and propylene glycol (co-surfactant) were chosen. In comparison to Km 1 and Km 2, Km=3 was chosen for the preparation of SNEDDS of cinnamon oil because it shows the best Nano emulsion region. The pseudo ternary phase diagram was produced with the medication present to determine the emulsification range and to assess the effect of cinnamon oil on the phase's emulsification behavior. The main feature of these systems is their ability to produce an oil in water (o/w) emulsion or micro emulsion after dilution by an aqueous phase with modest agitation. The improved formulation was next tested for thermodynamic stability, rheology, percent transmittance, cloud point, drug content, FTIR, particle size distribution, and zeta potential to ensure that the created SNEDDS formulation was stable.

Cinnamon oil, SNEDDS, solubility, surfactant, improving bioavailability

"Formulation And Evaluation of Self Nano emulsifying Drug Delivery System of Poorly Water Soluble Drug", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 3, page no.e595-e605, March-2022, Available :http://www.jetir.org/papers/JETIR2203476.pdf

"Formulation And Evaluation of Self Nano emulsifying Drug Delivery System of Poorly Water Soluble Drug", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 3, page no. ppe595-e605, March-2022, Available at : http://www.jetir.org/papers/JETIR2203476.pdf