• Subrata Paul
• Madhu Sahu
• Preetam Mandal
• Aysha Quraishi
• Sourabh Dixit

Xanthan gum is a microbial high molecular weight exo-polysaccharide produced by Xanthomonas bacteria (a Gram-negative bacteria genus that exhibits several different species) and it has widely been used as an additive in various industrial and biomedical applications such as food and food packaging, cosmetics, water-based paints, toiletries, petroleum, oil-recovery, construction and building materials, drug delivery. In Novel Drug Delivery System drug is targeted to the specific site of action to avoid 1st pass metabolism. For these types of dosage system conventional dosage forms are modified and designed to get approximately 100% of drug effect. Thus tablets, patches, hydrogels, microcapsules etc. forms of dosage are preparing in now days. To prepare this type of dosage forms controlled and sustained release polymers are added to provide precise amount of drug in time. Xanthan gum is one of the most useful natural polymers which is used to prepare dosage forms. To improve the efficiency and extended release pattern of the drug xanthan gum is modifying by processing chemical reactions such as carboxylation, acetylation, methylation, maleate reaction etc. these reactions helps to produce xanthan gum derivatives which is using in different types of hydrogels, tablets, patches etc. Xanthan gum is a high molecular weight extracellular polysaccharide. It is hydrophilic polymer, which until recently had been limited for use in thickening, suspending and emulsifying water-based systems. Xanthan gum derivatives are commonly used with other base materials like chitosan, acrylamide, poly vinyl alcohol, sodium alginate to make the formulation more stable. To evaluate the stability and therapeutically effect and the release order different type of analysis methods are used such as DSC, TGA, Swelling index, Release profile, Morphological examination, X-ray diffraction, TEM, SEM etc.

Xanthan gum, carboxymethylation, decarboxylation, acetylation, tramadol, microencapsulation, tablets.

"A Peer Review Of Xanthan Gum Derivatives In Development Of Drug Delivery Systems", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 4, page no.a342-a368, April-2022, Available :http://www.jetir.org/papers/JETIR2204045.pdf

"A Peer Review Of Xanthan Gum Derivatives In Development Of Drug Delivery Systems", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 4, page no. ppa342-a368, April-2022, Available at : http://www.jetir.org/papers/JETIR2204045.pdf