• Dinesh Kawade
• Mayank Pandey
• Mohammad Qutub
• Mohit Bakshe
• Neha Gotmare, Nikita Shukla

Computer aided drug design (CADD) is an evolving cascade of research area encompassing many facets. Computer-aided drug design (CADD) is an exciting and diverse discipline where various aspects of applied and basic research merge and stimulate each other. The theoretical basis of CADD involves quantum mechanics and molecular modelling studies like structure-based drug design; ligand-based drug design; database searching and binding affinity based on the knowledge of a biological target. In this present review we present the areas where CADD tools support drug discovery process. In this survey we present the essential data about diabetes, different kinds of diabetes; its impact on climate, its different signs and side effects, different ID test for diabetes, use and job of insulin in diabetes, its avoidances, Treatment for diabetes, drugs given in treatment of diabetes, different classes of medication used to treat diabetes, instrument of activity of dipeptidyl peptidase-4 inhibitor. Other than this audit likewise centers around in silico screening of vildagliptin and its analogs. Construction of vildagliptin, its property, its bioactivity examined with the assistance of molinspiration. Analogs of vildagliptin were made with the assistance of Chemsketch. Avogadro was utilized to change over .mol record to .pdb. With the assistance of protein information bank receptor was download in .pdb design. Pyrx was utilized to check binding liking of analogs with receptor and analogs are contrasted and primary medication. Furthermore, best medication's atomic mechanics, energy computation, and so forth and this is finished with BIOVIA revelation studio. In which R10 was found to tie with receptor more proficiently than that of vildagliptin, though some simple showed lower binding effinity than that vildagliptin.

Molecular Docking, Vildagliptin, Dipeptidyl Peptidase-4 Inhibitor, In Silico screening, Diabetes

"IN SILICO SCREENING AND MOLECULAR DOCKING OF ANALOGUES OF VILDAGLIPTIN AS A DIPEPTIDYL PEPTIDASE-4 INHIBITOR IN TREATMENT OF DIABETES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 4, page no.c207-c220, April-2022, Available :http://www.jetir.org/papers/JETIR2204229.pdf

"IN SILICO SCREENING AND MOLECULAR DOCKING OF ANALOGUES OF VILDAGLIPTIN AS A DIPEPTIDYL PEPTIDASE-4 INHIBITOR IN TREATMENT OF DIABETES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 4, page no. ppc207-c220, April-2022, Available at : http://www.jetir.org/papers/JETIR2204229.pdf