• Ms. Shaily Tyagi
• Mr. Mohit Panwar
• Mr. Shivdhar Sonkar
• Mr. Saket Saini
• Mr. Rahul K.Prabhakar

Background: There are numerous malignancies afflicting the human body and are characterized by fast growth, invasiveness and metastatic potential. There are various treatment methods such as – surgery, chemotherapy, radiation therapy and most recently, immunotherapy that have been routinely used. However, these treatment modalities are associated with significant morbidities and can sometimes, cause mortality, also. However, there is a need to channelize alternative treatment options such as use of plant extracts to minimize this side – effect. Objective: The aim of this comparative study was to analyze effectiveness of oral curcumin when used in solid tumor patients in relation to clinical parameters along with biochemical markers. Objective included-a) observe patient’s demographic data, b) investigate solid tumor, c) identification of effectiveness of oral dosage and d) evaluation of its overall effects on weight, behavioral changes and adverse drug reaction. Methods: A total of 40 patients diagnosed with solid tumors were included in the study. Oral curcumin (500mg) was administered to the patients along with other chemotherapy and supportive agent. The recorded responses were grouped under the following categories- a) improvement in markers, c) deterioration in condition despite curcumin use and d) No improvement were seen and patients were in stable condition. Result: The highest incidence of solid tumor of cancer was noted in patients between 46 to 50 years age range while extremely significant between (P<0.0001) in improvement in all clinical condition (appetite, pain, vomiting and weight) were observed in all the studied type of cancer. Although, none of the analyzed biochemical markers showed any statistically significant difference (P=1.000) in improvement. Conclusion: Although there were significant improvement observed in studied clinical parameters, no significance was seen in biochemical markers. It can be concluded that large sample sized should be studied to critically evaluate the advantages of using curcumin in drug therapy

To study the effects of oral curcumin on solid tumor patients in reference to clinical parameter and biochemical markers.

"THE EFFECT OF ORAL CURCUMIN ON SOLID TUMORS OF PATIENTS IN REFERENCE TO CLINICAL PARAMETER AND BIOCHEMICAL MARKERS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 4, page no.c581-c600, April-2022, Available :http://www.jetir.org/papers/JETIR2204284.pdf

"THE EFFECT OF ORAL CURCUMIN ON SOLID TUMORS OF PATIENTS IN REFERENCE TO CLINICAL PARAMETER AND BIOCHEMICAL MARKERS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 4, page no. ppc581-c600, April-2022, Available at : http://www.jetir.org/papers/JETIR2204284.pdf