• Anil Binjhade
• Manohar Rao Gawande
• Vinoy Kumar Shrivastava

Present investigation aimed to study, whether para-nonylphenol (p-NP) induced, oxidative stress in the liver of male Mus musculus and co-administration of ascorbic acid can ameliorate any possible oxidative stress. For which 20 male Mus musculus (P) were divided in to four groups of 5 each. Group I served as control receved normal diet and water adlibitum, group II exposed with (250 mg/kg/0.2ml/day) para-nonylphenol orally and Group III exposed with para-nonylphenol along with co-administered with ascorbic acid (10ppm) and While, Group IV supplemented with ascorbic acid alone for 30 and 60 days, and hepatic histopathological, enzymological i.e. GOT, GPT, ACP and ALP and biochemical parameter i.e. cholesterol and creatinine levels were carried out. In histological observations, noted that para-nonylphenol induced hypertrophied, degenerative and pyeknotic change in hepatocytes after 30 and 60 days. While, the animals supplemented with vitamin-C alongwith para-nonylphenol up to 30 and 60 days showed recoveries in hepatic cells. In connection to this, the enzyme activities i.e. GOT, GPT, ACP and ALP and biochemical parameter i.e. cholesterol and creatinine levels were significantly elevated by para-nonylphenol in 30 and 60 days treatement, However, there change were become lowered towards normalcy when vitamin-C supplemented alongwith para-nonylphenol.

para-Nonylphenol, ascorbic acid, enzymes, Mus musculus, histopathology, oxidative damage.

"“Ameliorative role of Ascorbic acid against para-nonylphenol induced toxicity in liver of male Mus musculus (P)”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 4, page no.d591-d598, April-2022, Available :http://www.jetir.org/papers/JETIR2204373.pdf

"“Ameliorative role of Ascorbic acid against para-nonylphenol induced toxicity in liver of male Mus musculus (P)”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 4, page no. ppd591-d598, April-2022, Available at : http://www.jetir.org/papers/JETIR2204373.pdf