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April-2022
eISSN: 2349-5162
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Journal of Emerging Technologies and Innovative Research ( An International Scholarly Open Access Journal, Peer-reviewed, Refereed Journal )
Impact factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal
UGC Approved Journal no 63975(19)
ISSN: 2349-5162 | ESTD Year : 2014 Call for Paper
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UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975
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Published Paper ID:
JETIR2204376
Registration ID:
400620
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Title
Evaluation Of Nootropic Activity Of Polyherbal Formulation By Using Object Recognition Test And Reversal Of Diazepam Induced Amnesia By Using Y-Maze
Authors
Abstract
Polyherbal formulation consists of plant ingredients of Brahmi (Bacopa monniera), Shatavari ( Asparagus racemosus), and Ashwagandha (Withania somnifera).The present study was undertaken to investigate the effects of Polyherbal formulation (PHF) on learning and memory in experimental animals. Object Recognition Test and Y- maze were employed to test learning and memory. Diazepam (1mg/kg p,o) was used as interoceptive (stimulus inside the body) behaviour model. Three doses (100,300 and 600 mg/kg p.o.) of PHF were selected depending upon the acute oral toxicity study observations and were administered in separate groups of animals.Object recognition test results proved the efficacy of the polyherbal formulation as a nootropic by significantly increasing the discrimination index at dose of 300 mg/kg.The Y-maze model results also showed that dose of 300mg/kg of PHF significantly improved learning and memory in rats. Furthermore, this dose significantly reversed the amnesia induced by diazepam (1mg/kg p,o.). Diazepam which is a GABA mimetic agent induces memory impairment and the subsequent inhibition of diazepam induced amnesia by the PHF may be due to inhibition of GABA-B receptors which in turn facilitate learning and memory.
Key Words
Polyherbal Formulation (PHF),Amnesia,Learning,Memory,Nootropic.
Cite This Article
"Evaluation Of Nootropic Activity Of Polyherbal Formulation By Using Object Recognition Test And Reversal Of Diazepam Induced Amnesia By Using Y-Maze", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 4, page no.d608-d614, April-2022, Available :http://www.jetir.org/papers/JETIR2204376.pdf
ISSN
2349-5162 | Impact Factor 7.95 Calculate by Google Scholar
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Cite This Article
"Evaluation Of Nootropic Activity Of Polyherbal Formulation By Using Object Recognition Test And Reversal Of Diazepam Induced Amnesia By Using Y-Maze", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 4, page no. ppd608-d614, April-2022, Available at : http://www.jetir.org/papers/JETIR2204376.pdf
Publication Details
Published Paper ID: JETIR2204376
Registration ID: 400620
Published In: Volume 9 | Issue 4 | Year April-2022
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.35038
Page No: d608-d614
Country: Pune, Maharashtra, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication
Published Paper URL :: https://www.jetir.org/view?paper=JETIR2204376
Published Paper PDF: https://www.jetir.org/papers/JETIR2204376
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