• Ms.Rohini R.Naik
• Ms.Ashwini S.Pandav
• Dr.Nilesh B.Chougule
• Ms.Mayuri S.Bhadalekar
• Ms.Mayuri S. Bhosale

In this research, influence the physicochemical properties were improved utilising ultrasound (US) and the Antisolvent sonocrystallization technology (ASC) of Atorvastatin Calcium (AC). The study is carried out to optimize the small particles of AC along with the stabilizers like poloxamer188 and polyvinyl pyrrolidone K-30 (PVP) in the concentration of 0.04% and US amplitude of 102% for different time intervals such as 5min, 10min and 15min in the antisolvent solution at 37° C. The application of ultrasonication effect resulted in a decrease in particle size, up to 1 to 4µm of both the batches A3 and B3, where the particle size of pure drug was found to be 15.92 µm. The rate and extent of dissolution were enhanced significantly almost 99.07% drug was released from batch A3 and 89.77% drug was released from batch B3, as compared with pure drug (AC) 32.5%. Saturation solubility of both the batches A3 and B3 was increased, two times than the pure drug (AC) after giving ultrasound Effect. Presence of characteristic peaks of AC in FTIR spectra’s of prepared; might confirm that there is no interaction between drug and polymer. From DSC and XRD data it is clearly manifested that crystallinity of AC has reduced with increase in sonication time. Fast dissolving tablets of optimized batch were prepared by using super disintegrant crosscarmellose (Ac-Di-Sol). Prepared fast dissolving tablet of optimized batch had shown superior dissolution profile than that of marketed tablet. The result of accelerated stability study concludes the prepared fast dissolving tablet was stable enough at 45⁰C/ 75% RH for three months. Therefore Ultrasonication is an interesting technique to increase solubility of drugs with poor water solubility which was successfully developed for engineering small particles of Atorvastatin.

Key words: Antisolvent Sonocrystalisation, Atorvastatin, Poloxamer 188, PVP K-30, physicochemical properties, Dissolution, DOE, fast dissolving tablet.

"‘ANTISOLVENT SONOCRYSTALISATION OF ATORVASTATIN: EFFECT OF ULTRASOUND ON PHYSIOCHEMICAL PROPERTIES’", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 4, page no.e146-e163, April-2022, Available :http://www.jetir.org/papers/JETIR2204422.pdf

"‘ANTISOLVENT SONOCRYSTALISATION OF ATORVASTATIN: EFFECT OF ULTRASOUND ON PHYSIOCHEMICAL PROPERTIES’", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 4, page no. ppe146-e163, April-2022, Available at : http://www.jetir.org/papers/JETIR2204422.pdf