• Mr. Ajay D. Dhoom
• Mr. Ashvin J. Bhagariya
• Nitin G. Saharya
• Jitu A. Pawar
• Satish L. Vagh

A novel technique, pastillation to fabricate lipid based oral multiparticulate controlled release dosage forms for time in pharmaceutical field is reported. An in-house laboratory scale device was designed to generate pastilles of doxofylline loaded stearic acid. Pastilles formed were characterized for drug content uniformed, drug release profile ,morphology and contact-angel .The optimized condition for pastillation were 1.00cm dropping height, 20G ,need orifice and 4ºC plate temperature which produced good pastilles of uniform size (2.5-3.0 mm) with contact angle above 90º. This multiparticulate system has very good flow property and is very uniform in size, weight and drug content and is able to sustain the drug release for a period of 24h. This is a very simple method for producing lipid-based multi-particulate system as compared to other available techniques (meltextrusion and freeze-pelletization) which can further be filled in capsule/sachets. The biggest advantage of this technology is that the large-scale equipment for pastillation is well-established in chemical industries. Therefore, use of this unique dosage form mayopen new avenue in the field of drug delivery which may even be an alternative for line extension or preparing patent non-infringing product of existing formulation.

Principle, Suitable Polymer for pastillation, Method, Case Study, Evaluation of Pastilles, Application, Limitation I

"A REVIEW: NOVEL TECHNIQUES FOR CONTINUES MANUFACTURING PROCESS: PASTILLATION", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 4, page no.g483-g504, April-2022, Available :http://www.jetir.org/papers/JETIR2204673.pdf

"A REVIEW: NOVEL TECHNIQUES FOR CONTINUES MANUFACTURING PROCESS: PASTILLATION", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 4, page no. ppg483-g504, April-2022, Available at : http://www.jetir.org/papers/JETIR2204673.pdf