UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 9 Issue 4
April-2022
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2204803


Registration ID:
401378

Page Number

i15-i32

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Title

Formulation and Evaluation of Herbal Gel Containing Centipeda Minima Leaves Extract and Study of its Anti-Microbial and Anti-Inflammatory Activities

Abstract

The leaves of Centipeda minima were selected for the proposed study. The leaves were shade dried, extracted by decoction method and the prepared herbal extract powder was evaluated for phytochemical screening tests such as, physical evaluation, test for alkaloids, test for proteins, test for glycosides, test for carbohydrates and sugars, test for tannins and phenolic compounds, test for flavonoids, test for steroids and test for fixed oils and fats. The Centipeda minima extract was subjected to preformulation studies such as drug - excipient interaction study by FT-IR and identification of chemical compounds by GC-MS analysis.The present study was undertaken to formulate centipeda minima herbal gel using three different gelling agents such as Carbopol 934, HPMC K 100 M and Xanthan gum. A total of six formulations were prepared. The formulated gel were evaluated for physical appearance, pH, spreadability, estimation of drug content, in-vitro diffusion study, stability study anti-microbial and anti-inflammatory activity. Formulation F6 containing centipeda minima along with xanthan gum as gelling agent showed better spreadability(29.65%), maximum drug content (73.82%), faster drug release (78.4%), promising anti-microbial and anti-inflammatory activity. Based on the study of pH, spreadability, drug content, stability, in-vitro drug release, anti-inflammatory and anti-microbial activity, formulation F6 containing centipeda minima and xanthan gum emerged as the best formulation for topical application.

Key Words

Centipeda minima, Anti-microbial, Anti-inflammatory, Carbopol 934, Xanthan gum, HPMC K 100 M.

Cite This Article

"Formulation and Evaluation of Herbal Gel Containing Centipeda Minima Leaves Extract and Study of its Anti-Microbial and Anti-Inflammatory Activities", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 4, page no.i15-i32, April-2022, Available :http://www.jetir.org/papers/JETIR2204803.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Formulation and Evaluation of Herbal Gel Containing Centipeda Minima Leaves Extract and Study of its Anti-Microbial and Anti-Inflammatory Activities", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 4, page no. ppi15-i32, April-2022, Available at : http://www.jetir.org/papers/JETIR2204803.pdf

Publication Details

Published Paper ID: JETIR2204803
Registration ID: 401378
Published In: Volume 9 | Issue 4 | Year April-2022
DOI (Digital Object Identifier):
Page No: i15-i32
Country: Sivakasi, Tamilnadu, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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