• Asha M
• Preethi T
• Jayaprakash U
• Arul Prakasam K C

Parkinson disease is the second most prevalent neurodegenerative illness. Parkinson disease is a chronic, progressive disease that affects 1% of people over the age of 60. The disease progresses vary in people, with those diagnosed early in life living longer than those diagnosed later in life. The clinical features typically associated with Parkinson's disease are tremor, rigidity, and bradykinesia, with postural instability frequently appearing as the disease progresses. A thorough history and physical examination should be included in the differential diagnosis of Parkinson's disease. It is a complex neurodegenerative disease with a wide range of motor and non-motor symptoms that necessitate an individualized care plan. Monoamine oxidase-B (MAO-B) inhibitor is generally the first step in monotherapy. If motor fluctuations develop, consider adding a catechol-O-methyltransferase (COMT) inhibitor to extend the duration of levodopa activity. Consider using an MAO-B inhibitor or a dopamine agonist instead. Consider adding amantadine to the treatment of levodopa-induced peak-dose dyskinesias. Although there is no known cure for Parkinson's disease, alternative drug, surgical, and behavioral therapies are available, and new treatments are being developed to help alleviate the adverse effects and symptomatology of this progressive disease.

Parkinson disease, alpha synuclein, tremor, levodopa

"A Review On Parkinson’s Disease: Etiology ,Pathophysiology, Diagnosis and its Various Managements.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 5, page no.c703-c720, May-2022, Available :http://www.jetir.org/papers/JETIR2205393.pdf

"A Review On Parkinson’s Disease: Etiology ,Pathophysiology, Diagnosis and its Various Managements.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 5, page no. ppc703-c720, May-2022, Available at : http://www.jetir.org/papers/JETIR2205393.pdf