• Sonu Dwivedi
• Dr. Jitendra Banweer
• Dr. Abhishek Banke

The pH-sensitive ophthalmic in situ gel of Diclofenac sodium was successfully formulated by using TSP as gelling agent and Sodium CMC as viscosity enhancer and release retardant. The formulated pH sensitive in situ gels were then evaluated for appearance, clarity, pH, gelling capacity, refractive index, drug content, viscosity, sterility, antimicrobial efficacy, ocular irritation and in vitro release in artificial tear fluid. The formulations were liquid at around pH 6 and underwent rapid gelation upon raising the pH to 7.0. The gels were stable for the period of 8 hours and provided delayed release. Response surface design, regression analysis, contour and surface plots, and desirability function obtained from response optimizer have been proven to be a useful approach for the optimization of formulations.

Ophthalmic delivery system, formatting, TSP, Sodium CMC and Anatomy of Eye.

"FORMULATION AND EVALUATION OF OPHTHALMIC IN-SITU GEL OF DICLOFENAC SODIUM USING NATURAL GELLING AGENT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 5, page no.g698-g708, May-2022, Available :http://www.jetir.org/papers/JETIR2205782.pdf

"FORMULATION AND EVALUATION OF OPHTHALMIC IN-SITU GEL OF DICLOFENAC SODIUM USING NATURAL GELLING AGENT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 5, page no. ppg698-g708, May-2022, Available at : http://www.jetir.org/papers/JETIR2205782.pdf