• Amit Kumar Singh
• Jappreet Kaur

Abstract Glucose-6-phosphate dehydrogenase is an enzyme present in most human tissue, which is involve in the production of reduced glutathione (GSH) from oxidized glutathione (GSSH) in the hexose mono phosphate shunt (HMP shunt). The reduced glutathione (GSH) is a key product in the control of oxidative stress. If the activity of G-6-P-D defect by every reasons in the cells will lead to G-6-P-D deficiency. The deficiency of G-6-P-D is increased the level of oxidative stress which is causes diabetes mellitus type 2. It means that the G-6-P-D deficiency is one of the risk factor for development of diabetes mellitus type 2. So, diabetes mellitus type 2 is one of the life treating disease in many populations. The G-6-P-D deficiency is an X-linked hereditary disorder which is more common in men among the African countries. In this study I select one of the African countries “Ghana; west of Africa” which studied in the Centeral Regional Hospital located in Cape Coast in the central Region of Ghana. The prevalence of G-6-P-D deficiency studied by M.B Adinortey, R.K Owusu, I.K. A. Galyuon, W.Ekloh, I. Owusu and D.A. Larbi. The prevalence of G-6-P-D deficiency whichdeveloped the diabetes mellitus type 2 studied among the 422 participants (diabetic and non-diabetic participants). The prevalence G-6-P-D deficiency is more common in diabetic patients as compare as the non- diabetic participants. The treatment or prevention of G-6-P-D deficiency decreases the level of diabetic mellitus type 2 development.

G-6-P-D deficiency, diabetes mellitus type 2, oxidative stress, African countries.

"Development of diabetes mellitus, G-6-P-D deficiency is a potential risk factor", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 5, page no.g796-g801, May-2022, Available :http://www.jetir.org/papers/JETIR2205797.pdf

"Development of diabetes mellitus, G-6-P-D deficiency is a potential risk factor", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 5, page no. ppg796-g801, May-2022, Available at : http://www.jetir.org/papers/JETIR2205797.pdf