UGC Approved Journal no 63975(19)

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Published in:

Volume 9 Issue 5
May-2022
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2205A39


Registration ID:
403196

Page Number

j292-j302

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Title

A REVIEW ON NANOSTRUCTURED LIPID CARRIERS AS DRUG DELIVERY SYSTEM

Abstract

Now-a-days, nanocarrier drug delivery systems are proved to be the most efficient drug carrier systems. Nanoparticles contribute to site specific targeting thus preventing the degradation of drug from various physiological barriers. Amongst all advancing nano drug carriers, lipidic systems are considered to be the most evident. Hence, nanostructured lipid carriers are formed. These are the safe lipidic colloidal systems made up of liquid and solid lipid mixtures. The structure of these NLCs is imperfect that provides high drug loading capacity and long-term drug stability. The system is stabilized using surfactants. This lipidic formulation provides increased drug solubility, enhanced permeation, prolonged half-life, reduced clearance and enhanced bioavailability of different class of drugs. The in-vitro drug release studies show different release kinetics of drug. The in- vivo studies showed better permeation of drug into the system and better safety profiles of drug. This ultimately leads to increased safety and efficacy of drugs causing increased patient compliance. these lipidic nano-formulations can be administered through various routes based on the therapeutic action needed. Due to their adhesive property to mucus the orally administered ones are more useful for treatment of local GIT and pulmonary infections. Also, nose to brain delivery of many drugs that do not cross blood brain barrier due to their non-lipophilic nature can be administered in the form of NLCs to increase the bioavailability of drug in brain. Due to the different applications of NLCs such as oral, topical, ocular and pulmonary the formulation is considered to be the most emerging in class of lipidic-NPs.

Key Words

Nanocarriers, nanostructured lipid carriers, high drug loading, enhanced efficacy, lipidic-nanoparticles.

Cite This Article

"A REVIEW ON NANOSTRUCTURED LIPID CARRIERS AS DRUG DELIVERY SYSTEM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 5, page no.j292-j302, May-2022, Available :http://www.jetir.org/papers/JETIR2205A39.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"A REVIEW ON NANOSTRUCTURED LIPID CARRIERS AS DRUG DELIVERY SYSTEM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 5, page no. ppj292-j302, May-2022, Available at : http://www.jetir.org/papers/JETIR2205A39.pdf

Publication Details

Published Paper ID: JETIR2205A39
Registration ID: 403196
Published In: Volume 9 | Issue 5 | Year May-2022
DOI (Digital Object Identifier):
Page No: j292-j302
Country: Amravati, Maharashtra, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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