• Abhishek Abhayrao Joshi
• Dr. A.A. harsulkar
• Deepak Gadhave
• Maroti Pawar

An Orally disintegrating tablet disperses readily in saliva and the drug is available in solution or suspension form for the immediate absorption and resulting in rapid onset of action. In the present research work Modafinil Orally disintegrating tablet were prepared by wet granulation method using varying concentrations of Lycoat, Crosspovidone & Sodium alginate as superdisintegrants. The formulations prepared were evaluated for precompression & post compression parameters. Form the drug excipient compatibility studies we observe that there are no interactions between the pure drug (Modafinil) and optimized formulation (Modafinil+ excipients) which indicates there are no physical changes. Post compression parameters was found to be within the limits. Among the formulation prepared the tablet containing concentration of Crosspovidone shows 99.18% of the drug release within 10 min, 28 sec Disintegration time & follows first order kinetics. The overall result indicated that the formulation F8 containing Crosspovidone is better and fulfilling of the needs of the Orally disintegrating tablet.

Orally disintegrating tablet, Modafinil, Crosspovidone, Lycoat, superdisintegrant

"Design,Development and Characterization of orally disintegrating tablet for enhancing patient compliance", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 6, page no.b516-b541, June-2022, Available :http://www.jetir.org/papers/JETIR2206171.pdf

"Design,Development and Characterization of orally disintegrating tablet for enhancing patient compliance", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 6, page no. ppb516-b541, June-2022, Available at : http://www.jetir.org/papers/JETIR2206171.pdf