• Anjana Gupta
• Vishal shrivastava
• Pradeep K. Yadav
• Akhlesh K. Singhai

Medicinal plants have attracted great attention in the recent years and is increasingly applied instead of the chemical drugs .In the recent year’s different medicinal plants and their main components have been shown in psychotic therapy. The present study was carried out to evaluate the role of Nigella sativa (Black cumin) in animal model of antipsychotic activity. Thymoquinone is the main chemical constituents present in Nigella sativa and has various pharmacological activity. Dopamine is an inhibitory neurotransmitter involved in the pathology of antipsychotic. Thymoquinone (TQ) (20mg/kg, intraperitoneally) was administered daily for 28 days in mice. Different models of antipsychotic such as haloperidol - induced catalepsy ,Apo morphine –induced climbing behavior and elevated plus- maze test were used after the last dose of thymoquinone on the 28th day ,behavioral tests were performed followed by biochemical estimations. The present study observed antipsychotic actions in different animals models of antipsychotic and also improved memory. Our results are preliminary, further research is warranted to establish role of black cumin as a new candidate in antipsychotic.

Antipsychotic, Black cumin, Nigella sativa ,Thymoquinone ,Dopamine, Neurotransmitter.

"“Evaluation of anti-psychotic activity of Nigella sativa (Black cumin)”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 6, page no.b599-b619, June-2022, Available :http://www.jetir.org/papers/JETIR2206181.pdf

"“Evaluation of anti-psychotic activity of Nigella sativa (Black cumin)”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 6, page no. ppb599-b619, June-2022, Available at : http://www.jetir.org/papers/JETIR2206181.pdf