• Poonam Sunil Jadhav
• Komal Shivaji Awalekar
• Shraddha Nagtilak
• Ganesh S Andhale
• Prof. Jyoti Kadam

It is necessary for the drug to become soluble in order to generate the desired pharmacological reaction. Solubility is one of the most significant criteria for achieving the required drug concentration in systemic circulation and demonstrating pharmacological response. Medicine's therapeutic efficacy is determined by its bioavailability, which is determined by the solubility of the drug moiety. Several formulation techniques are now available to improve solubility and dissolution profile, which is helpful in increasing oral bioavailability. Nanocrystals are crystalline nanoparticles (200–500 nm) that contain a high concentration of medication and are stabilized by surface stabilizers. Hydrotrophy is a solubilization process in which the hydrotropic agent increases the water solubility of the first solute by adding a large amount of the second solute. Co-crystallization is one of the method of solubility enhancement which not only enhances the solubility of the drug but also brings a significant change in the physicochemical properties of the drug such as stability, bioavailability and dissolution rate. Combining poorly soluble pharmaceuticals with a water miscible solvent in which the drug is readily soluble can improve its water solubility. This is known as cosolvency, and the solvent that is used in conjunction is known as cosolvent. The cosolvent system reduces the interfacial tension between the aqueous solution and the hydrophobic solute.

Solubility, therapeutic efficacy, bioavailability, solubilization process, Co-crystallization Etc

"NOVEL SOLUBILIZATION TECHNOLOGY AN ECO-FRIENDLY ANALYSIS TO IMPROVE SOLUBILITY, DISSOLUTION, AND BIOAVAILABILITY OF VARIOUS POORLY WATER SOLUBLE NSAID DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 6, page no.c98-c113, June-2022, Available :http://www.jetir.org/papers/JETIR2206211.pdf

"NOVEL SOLUBILIZATION TECHNOLOGY AN ECO-FRIENDLY ANALYSIS TO IMPROVE SOLUBILITY, DISSOLUTION, AND BIOAVAILABILITY OF VARIOUS POORLY WATER SOLUBLE NSAID DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 6, page no. ppc98-c113, June-2022, Available at : http://www.jetir.org/papers/JETIR2206211.pdf