• Akshi Valodara
• Kaid Johar SR

Catalase is the most significant antioxidant enzymes and act as a main regulator of hydrogen peroxide (H2O2) mechanism against oxidative stress. It helps in maintaining essential biomolecules from getting damaged by oxidative stress. Catalase takes part in several biological mechanisms such as apoptosis, inflammation, tumour mutagenesis as well as endocrine system. Imbalance level of catalase enzyme, promoter polymorphism and deregulation of catalase (CAT) gene expression level is linked with diseases including diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM). This article discusses the role of altered level of CAT gene regulation, polymorphism in promoter region and its enzyme activity is associated with DR in T2DM development.

Catalase, Oxidative stress, Type 2 diabetes, Diabetic retinopathy, Promoter polymorphism

"Role Of Catalase In Diabetic Retinopathy Of Type 2 Diabetes Mellitus", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 6, page no.d59-d64, June-2022, Available :http://www.jetir.org/papers/JETIR2206308.pdf

"Role Of Catalase In Diabetic Retinopathy Of Type 2 Diabetes Mellitus", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 6, page no. ppd59-d64, June-2022, Available at : http://www.jetir.org/papers/JETIR2206308.pdf