• Radhika Maroti Shrirao
• Dr. Bharati V. Bakde

:Solubility and dissolution-related bioavailability issues plague poorly water soluble substances. Orally administered medications account for over 90% of all pharmaceuticals. Pharmacological absorption, bioavailability, and pharmacokinetic profile of orally delivered drug substances are all largely dependent on the compound's solubility in aqueous media. Solid dispersion has been proven to be a superior dose form for medicines with poor water solubility. Solid dispersions in water-soluble carriers have piqued interest as a technique of enhancing hydrophobic medication dissolution rates and bioavailability. solid dispersion, micronization, and salt creation are all important ways for improving the solubility of poorly soluble pharmaceuticals, but each has its own set of limitations and benefits. The basic notion of solid dispersion, numerous forms of solid dispersion, preparation and characterisation methods, advantages, limitations, and applications are all discussed in this article

Dissolution, Bioavailability, Solid dispersion, Carriers, Solubility.

"Solubility Enhancement of Poorly Water Soluble Drugs By Solid Dispersion Technique", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 6, page no.d138-d152, June-2022, Available :http://www.jetir.org/papers/JETIR2206318.pdf

"Solubility Enhancement of Poorly Water Soluble Drugs By Solid Dispersion Technique", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 6, page no. ppd138-d152, June-2022, Available at : http://www.jetir.org/papers/JETIR2206318.pdf