• Bhand Ajay Rajendra
• Prof. Kadam Vaibhav Nivruti
• Sable Dnyaneshwar Rameshwar
• Datta Chaudhari Manjaba

Dolasetron mesylate, a derivative of carbazole, is a selective and competitive antagonist of serotonin 5-HT3 receptors. 5-HT3 receptors are present in the central and peripheral nervous system and are associated with various physiological and pathological processes mediated by serotonin. 5-HT3 receptor antagonists may be effective in mitigating the abuse of a variety of psychotropic substances, such as alcohol and cocaine. Dolasetron Mesylate blocks the actions of chemicals in the body which can cause nausea and vomiting. Dolasetron Mesylate is used to prevent nausea and vomiting which can be caused by surgery or drugs to treat cancer (chemotherapy or radiation). Dolasetron Mesylate is not indicated for the prevention of nausea or vomiting caused by factors other than cancer treatment or surgery. Aim of the present work is to formulate and Evaluate Dolasetron mesylate mucoadhesive tablets by using Moringa gum and Xanthan gum as a polymer. Moringa gum was used as thickening agent and Xanthan gum was used as polymers. The tablets were formulated by direct compression method and were evaluated for various pre-compression & post-compression parameters, such as hardness, thickness, friability, weight variation, drug content uniformity studies, swelling index studies, dissolution study, in-vitro dissolution studies.

Dolasetron mesylate, mucoadhesive tablets, moringa gum, xanthan gum

"FORMULATION AND EVALUATION OF DOLASETRON MESYLATE MUCOADHESIVE TABLET BY USING MORINGA GUM AND XANTHAN GUM AS POLYMERS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 6, page no.e466-e488, June-2022, Available :http://www.jetir.org/papers/JETIR2206456.pdf

"FORMULATION AND EVALUATION OF DOLASETRON MESYLATE MUCOADHESIVE TABLET BY USING MORINGA GUM AND XANTHAN GUM AS POLYMERS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 6, page no. ppe466-e488, June-2022, Available at : http://www.jetir.org/papers/JETIR2206456.pdf