• Karthik D
• Arumugham M.N

The synthesized new commercial ligand copper (II) complex [Cu (4-methyl-1,10-phen) (5,6-epoxy-1,10-phen) NO3]NO3·H2O, confirmed by IR, elemental analysis, EPR and UV–Vis studies. This Cu (II) ion adopts a fashioned by two N atoms from the 4-methyl-1,10-phenligand and another two N atoms of the 5,6-epoxy-1,10-phen ligands and one more NO3 atom. The nitrogen connected with the central metal atom. The Copper(II) metal complex are consist by energy holes of frontier orbital (HOMO-LUMO) considered with B3LYP /6-31G/LANL2DZ level of theory in the gaseous phase. Theoretical value can be calculated molecular orbitals (HOMO-LUMO) and their own energies, implying charge transport inside the complex. Moreover, the metal complex interacted with CT-DNA are confirmed about by UV–Vis absorption spectrum, EB displacement assay and CV studies. the pBR322 DNA cleavage with copper(II) metal complex have been analyzed by the gel electrophoresis method. The potent cytotoxic effects were against human cell line (HepG2) and The copper (II) metal complex has been discovered to have antimicrobial effects. Copper (II) metal Complex was bind to the DNA and intercalative mode and molecular docking analysis was supported out.

Six-coordinated Copper(II); Epoxy-phenanthroline; DFT analysis; DNA binding; DNA cleavage; Cytotoxicity

"SYNTHESIS, CHARACTERIZATION AND APPLICATION OF COPPER (II) COMPLEX WITH HETEROCYCLIC BASE IN DFT ANALYSIS, DNA STUDIES, CYTOTOXICITY AND MOLECULAR DOCKING STUDIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 6, page no.e617-e631, June-2022, Available :http://www.jetir.org/papers/JETIR2206472.pdf

"SYNTHESIS, CHARACTERIZATION AND APPLICATION OF COPPER (II) COMPLEX WITH HETEROCYCLIC BASE IN DFT ANALYSIS, DNA STUDIES, CYTOTOXICITY AND MOLECULAR DOCKING STUDIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 6, page no. ppe617-e631, June-2022, Available at : http://www.jetir.org/papers/JETIR2206472.pdf