• Upasana Sharma
• Priyanka Rathore
• Dr. R.B. Goswami

The fundamental objective of study formulation of cinnarizine microspheres for cause of nausea, vomiting and irritable bowel syndrome. To benefits of microspheres properties it has protecting medication of early degradation, achieved targeted drug release kinetics, Effect of concentration of superdisintegrant, reduced the lag time of drug, increase the bioavailability, maintain the drug dosing criteria, to prevent the loss of drug, to achieved the multiple dosing criteria, increase duration “t” half of drug. Development of cinnarizine microsphere criteria is study the effect of various processes on difference variations, Investigate the impact of varying concentration of mucoadhesive polymer on release of medication, analyse the drug release data, The Cinnarizine microsphere formulation developed selective various polymers with the scientific lab code F1 to F6, All formulation has evaluate the following parameter, determination of micrometrics properties, determination of shape of microspheres, determination of percentage drug entrapment, determination of zeta potential, in-vitro drug release kinetics. The systematic formulation approach helped in understanding the effect of formulation processing variables like formulation of sustained release microsphere using solvent evaporation method.

Microspheres, Cinnarizine, Lag time, “t” half, Zeta potential, Targeted drug

"FORMULATION AND EVALUATION OF MICROSPHERES OF CINNARIZINE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 6, page no.g310-g324, June-2022, Available :http://www.jetir.org/papers/JETIR2206637.pdf

"FORMULATION AND EVALUATION OF MICROSPHERES OF CINNARIZINE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 6, page no. ppg310-g324, June-2022, Available at : http://www.jetir.org/papers/JETIR2206637.pdf