UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
Call for Paper
Volume 11 | Issue 3 | March 2024

JETIREXPLORE- Search Thousands of research papers



WhatsApp Contact
Click Here

Published in:

Volume 9 Issue 6
June-2022
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

7.95 impact factor calculated by Google scholar

Unique Identifier

Published Paper ID:
JETIR2206713


Registration ID:
403528

Page Number

h83-h93

Share This Article


Jetir RMS

Title

EFFECT OF POLYMERS AND DILUENTS ON MUCOADHESIVE BILAYERED BUCCAL TABLETS OF ONDANSETRON HCl

Abstract

The objective of this study was to develop effective bioadhesive buccal bilayered tablets comprising of drug containing bioadhesive layer and drug free backing layer, expected to release the drug in unidirectional for extended period of time. Tablets of ondansetron HCl were prepared by direct compression method using bioadhesive polymers like Carbopol 934P, Methocel K4M, Methocel K15M and Hydroxy propyl cellulose in different combinations and concentrations with backing layer of ethyl cellulose. Buccal tablets were evaluated by different parameters such as thickness, hardness, weight uniformity, content uniformity, swelling index, surface pH, ex vivo bioadhesive strength, ex vivo residence time, in vitro drug release, ex vivo drug permeation, stability studies in human saliva, in vivo mucoadhesive performance studies and FTIR studies. The optimized formula (F32) followed non-fickian release mechanism with zero order kinetics. Carbopol 934P and HPC in the ratio of 3:1 could be used to design effective and stable buccoadhesive tablets of ondansetron HCl. The present study concludes that buccal delivery of Ondansetron HCl tablets can be good way to bypass the first pass metabolism.

Key Words

Bioadhesive buccal bilayered tablets, Direct compression, Ondansetron HCl

Cite This Article

"EFFECT OF POLYMERS AND DILUENTS ON MUCOADHESIVE BILAYERED BUCCAL TABLETS OF ONDANSETRON HCl", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 6, page no.h83-h93, June-2022, Available :http://www.jetir.org/papers/JETIR2206713.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"EFFECT OF POLYMERS AND DILUENTS ON MUCOADHESIVE BILAYERED BUCCAL TABLETS OF ONDANSETRON HCl", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 6, page no. pph83-h93, June-2022, Available at : http://www.jetir.org/papers/JETIR2206713.pdf

Publication Details

Published Paper ID: JETIR2206713
Registration ID: 403528
Published In: Volume 9 | Issue 6 | Year June-2022
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.30706
Page No: h83-h93
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


Preview This Article


Downlaod

Click here for Article Preview

Download PDF

Downloads

000180

Print This Page

Current Call For Paper

Jetir RMS