UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 9 Issue 6
June-2022
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Unique Identifier

Published Paper ID:
JETIR2206725


Registration ID:
404768

Page Number

h193-h208

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Title

Development And Characterization Of Dry Powder For Inhalation To Improve Delivery Of Poorly Water Soluble Drug

Abstract

The newly synthesized active pharmaceutical ingredients(API) have problem related to their solubility.In this study, we have developed a alternative method to increase the solubility of poorly water soluble drug. Inhalable dry powder was formulated by using spray drying process which helps to enhance the solubility of drug as well as bioavailability. The bosentan microparticles were prepared by the spray drying method with bosentan hydrate and mannitol at different weight ratios. The bosentan microparticles were then characterized for their physicochemical properties, FTIR study, Spectroscopic studies, Morphology, Particle Size Distribution, in vitro dissolution behavior, Drug content. In vitro dissolution behavior were performed by Franz diffusion cell. The results were evaluated by comparing their dissolution rate compared to pure bosentan hydrate. The highest performance bosentan microparticles, named F1(1:1) had irregular shape and porous shape. The particle size of F1(1:1) also matches the range for inhalation route.In conclusion, F1 (1:1) showed promising in vitro results with the dry powder inhalation. The inhaled bosentan microparticles can be considered as a potential alternative to oral bosentan hydrate.

Key Words

Dry powder Inhaler, Spray Drying, poorly water soluble, Microparticle, Inhalation route

Cite This Article

"Development And Characterization Of Dry Powder For Inhalation To Improve Delivery Of Poorly Water Soluble Drug", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 6, page no.h193-h208, June-2022, Available :http://www.jetir.org/papers/JETIR2206725.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Development And Characterization Of Dry Powder For Inhalation To Improve Delivery Of Poorly Water Soluble Drug", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 6, page no. pph193-h208, June-2022, Available at : http://www.jetir.org/papers/JETIR2206725.pdf

Publication Details

Published Paper ID: JETIR2206725
Registration ID: 404768
Published In: Volume 9 | Issue 6 | Year June-2022
DOI (Digital Object Identifier):
Page No: h193-h208
Country: Yavatmal, Maharashtra, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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