• Alok Kumar Mishra
• Prof. (Dr.) Pranav Kumar Upadhyay
• Prof. Rajeev Shukla

Background: low solubility affects dissolution leads to low bioavailability hence formulation come to less effective therefore it is required to enhance solubility in order to increase bioavailability. Sulfamerazine is a potent antibacterial drug comes in BCS class II category whose limited water solubility causes poor bioavailability. Objective: To enhance solubility and dissolution of Sulfamerazine by using solvent evaporation method of solid dispersion. Method: In order to get enhanced solubility of sulfamerazine (SMZ), solvent evaporation technique was adopted from solid dispersion techniques due to its easy procedure and minimum resources involved. Poloxamer 700 was used to enhance solubility of SMZ. All the required evaluation test were performed and optimized. Result: solid dispersion of sulfamerazine was prepared and evaluated, T1 formulation was found to be better optimized formulation. All the formulations were tested for %age yield, drug content, solubility, In-vitro dissolution test whose result was found to be 62.4 ± 1.232, 87.56 ± 5.321, 0.486 ± 0.124 and 87.65 % in 8 hours respectively for optimized formulation T1.

Solid dispersion, Solvent evaporation method, Sulfamerazine, solubility.

"Improvement of Dissolution rate of Sulfamerazine by Solid dispersion technique", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 7, page no.a714-a720, July-2022, Available :http://www.jetir.org/papers/JETIR2207088.pdf

"Improvement of Dissolution rate of Sulfamerazine by Solid dispersion technique", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 7, page no. ppa714-a720, July-2022, Available at : http://www.jetir.org/papers/JETIR2207088.pdf