• Sneha Suryakant Pabitwar
• Suchita Dhamane

Acne vulgaris is one of the most common skin illnesses, caused by excessive production of oil in the sebaceous glands, afflicting over 80% of all teenagers worldwide during their lifetime. Because of negative side effects associated with synthetic medications, the use of herbal medication has increased. Selected drug Cynodon dactylon hydrophobic in nature which limit therapeutic concentration of drug at target site. C. dactylon contain ferulic acid as an active constituent confirmed by HPTLC analysis.MIC value of C. dactylon against P. acne was 0.624 mg/ml. Chitosan nanoparticles are now thought to be most effective formulation; biocompatible, biodegradable, less harmful and easy to use in preparation. The objective of this study was to synthesis chitosan vanillin cross-linked nanoparticles and to formulate herbal topical nanogel to treat acne. The nanoparticles prepared by emulsion solvent evaporation method & characterized. The optimized batch of C. dactylon nanoparticles (F6) had particle size 320nm, PDI 0.5, Zeta potential (-22.7mV) & % EE 72.23±0.5 %. It was observed that as polymer concentration increases particle size & % EE also increases. These optimized nanoparticles transformed into topical nanogel. The gel formulation with 1% carbopol showed good pH, viscosity, homogeneity, spredability, % drug content (90.32±0.31 %) & % drug release (74.19±0.2 %), zero irritancy score & good antibacterial activity against P. acne. Hence, chitosan nanoparticles of C. dactylon in aqueous gel base can be used as an appropriate formulation to treat acne vulgaris.

Cynodon dactylon, Nanoparticles, Chitosan, Vanillin, Nanogel, Acne

"Formulation and Evaluation of Topical Delivery System for the Treatment of Acne Vulgaris.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 7, page no.e38-e44, July-2022, Available :http://www.jetir.org/papers/JETIR2207405.pdf

"Formulation and Evaluation of Topical Delivery System for the Treatment of Acne Vulgaris.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 7, page no. ppe38-e44, July-2022, Available at : http://www.jetir.org/papers/JETIR2207405.pdf