• Dr. Geeta K Patel
• Jayant Patel

The present work was aimed to enhance the dissolution rate of Rivaroxaban by delivering the drug as a liquisolid compact. The liquid solid technique is an innovate technique used in improved dissolution rate. Liquisolid compacts were prepared using Tween 80 as solvent, Avicel PH112 and 200 as carrier, and Aerosil as the coating material. The interaction between excipients was examined using physical mixing and differential scanning calorimetric method. The dissolution studies for the liquisolid formulation and the marketed product were carried out. The results showed no change in the crystallinity of the drug and no interaction between excipients. The dissolution efficiency of Rivaroxaban liquisolid formulation at 15 min was greater than that of innovator product. The increase in the dissolution rate was also found to be significant compared to the marketed product. The liquisolid technique appears to be a promising approach for improving the dissolution of poorly soluble drugs like Rivaroxaban.

Rivaroxaban, liquisolid technique, liquid load factor, non-volatile solvent, carrier material, coating material

"FORMULATION AND EVALUATION OF LIQUISOLID COMPACTS OF RIVAROXABAN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 7, page no.e152-e162, July-2022, Available :http://www.jetir.org/papers/JETIR2207421.pdf

"FORMULATION AND EVALUATION OF LIQUISOLID COMPACTS OF RIVAROXABAN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 7, page no. ppe152-e162, July-2022, Available at : http://www.jetir.org/papers/JETIR2207421.pdf