• Mahendra A. Giri
• K. Vanitha Prakash
• Sanjay B. Kasture

Parkinsons Disease is the most common progressive neurodegenerative movement disorder affecting more than 10 million people worldwide and the incidence of PD increases with the age. The degeneration of dopaminergic neurons is considered to be the root cause of the characteristic classical motor symptoms and nonmotor symptoms. Oxidative stress plays an important role in the pathogenesis of neurodegeneration. Nardostachys jatamansi are traditional herbs known to have neuroprotective and antioxidant effects. In the present study, comparative antiparkinsonian effect of hydroalcoholic extract of Nardostachys jatamansi (HENJ) on 6-OHDA-Lesioned Rat Model was studied and this experiment evaluated the effect on the hemiparkinsonism induced in rats. The results were analyzed by repeated measure ANOVA followed by Dunnett's test. In this study, the selected doses of HENJ at 30mg/kg &100mg/kg exhibited neuroprotective effect. These treatments increased contralateral turing behaviour indicative of antiparkinsonian activity.

Antiparkinsonian, 6-OHDA, Nardostachys jatamansi

"ANTIPARKINSONIAN EFFECTS OF Nardostachys jatamansi ON 6-OHDA-LESIONED RAT MODEL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 7, page no.e709-e720, July-2022, Available :http://www.jetir.org/papers/JETIR2207492.pdf

"ANTIPARKINSONIAN EFFECTS OF Nardostachys jatamansi ON 6-OHDA-LESIONED RAT MODEL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 7, page no. ppe709-e720, July-2022, Available at : http://www.jetir.org/papers/JETIR2207492.pdf