• Shital A. Zite
• Mr. K.G.Albhar

The present research is based on developing topical nanoparticles-foam formulation of clindamycin phosphate for the treatment of acne vulgaris. Foam is act as a best carrier system for the topical nanoparticles. Nanoparticles system have capacity to improve the topical drug delivery of drug because of their increasing drug loading potential, but the commercially use of nanoparticles in topical product is limited because the penetrate intact skin is contradictory and also their ability to release active agent in traditional semisolid vehicle is poor. To solve this problem foam formulation is developed. This is targeted or site specific formulation for the treatment of acne vulgaris. This foam formulation have the potential to break down the nanoparticles loaded within them improve the drug release from nanoparticles. Nanoparticles prepared by ionic elation nano-precipitation method by using the sodium alginate and guar gum biodegradable natural polymers. The DSC study of polymer with drug shows the endothermic peak at 95.866°C and the SEM study of batch shows the cubic shape nanoparticles and somewhat irregular shape and the drug being entrapped in the polymeric material. The entrapment efficiency of A4 batch is 75% greater than other all batches, on the basis of particle size ,zeta potential A4 batch shows the greater entrapment efficiency good in particle size and zeta potential. The cetyl alcohol and stearyl alcohol ration up to (60-40) or (80-20) help to maintain the foam characteristics ,make the foam quick breaking as well temperature sensitive.The HET-CAM test established non-irritancy of CLP nanoparticles loaded foam formulation.

Foam, Acne Vulgaris, Clindamycin phosphate, nanoparticles, polymer.

"Formulation And Evaluation Of Clindamycin Phosphate Nanoparticles Foam As a Carrier Drug Delivery System For The Treatment Of Acne Vulgaris.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 7, page no.f166-f175, July-2022, Available :http://www.jetir.org/papers/JETIR2207523.pdf

"Formulation And Evaluation Of Clindamycin Phosphate Nanoparticles Foam As a Carrier Drug Delivery System For The Treatment Of Acne Vulgaris.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 7, page no. ppf166-f175, July-2022, Available at : http://www.jetir.org/papers/JETIR2207523.pdf