• Abhishek Kumar Verma
• Tushar Verma

Modification of crystal by recrystallization alters physicochemical properties of the drug development of standard preformulation studies. The present aim of the study was achieved recrystallization of the drug to investigate effect of time and strength of electromagnetic filed on crystallization to improve the preformulation studies of Aspirin drug. The general application of crystallization is purification of drug, ease of handling, better chemical stability, better physical stability and improved bioavailability, better processing characteristics and sustained /controlled release on the bases of performed following parameters of Aspirin: physical appearance, melting point, determination of pH & dissolution. Aspirin used as model drug belonging from salicylic acid analogous which is used as antipyretic, anti-inflammatory and analgesic in verities of conditions ranging from headache, discomfort, and fever associated with the common cold, and muscular pains and aches. The study Report as well experimentation indicate simple crystallization require few hours to start nucleation followed by the crystal growth, while crystallization under electromagnetic field take less time for nucleation and crystal growth start within 2-10 minute, decreasing the time lag. Moreover the amount of nuclei formed is enormously increased in the time system. Increased in time of electromagnetic field exhibited appreciable change not only crystal morphology but also in the thermodynamic and other chemical properties. Hence preparation of crystal under electromagnetic field would offer advantages over simple crystallization and would be able to prepare desired crystal with better therapeutics.

Recrystallization, Electromagnetic filed, Lag time, Physical characterization, Therapeutics, Bioavailability.

"PREFORMULATION STUDIES: RECRYSTALLIZED CHARACTERIZATION OF ASPIRIN UNDER ELECTROMAGNETIC FIELD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 7, page no.f418-f440, July-2022, Available :http://www.jetir.org/papers/JETIR2207553.pdf

"PREFORMULATION STUDIES: RECRYSTALLIZED CHARACTERIZATION OF ASPIRIN UNDER ELECTROMAGNETIC FIELD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 7, page no. ppf418-f440, July-2022, Available at : http://www.jetir.org/papers/JETIR2207553.pdf