• hrutuja ragendra wagh
• Truti S.chitre
• Akash R. Pagare
• Laxmi chaudhary

QSAR studies were performed on a set of 324 analogs of 2,6-disubstituted 4,5,6,7-tetrahydrothieno[2,3-c] pyridine-3-3carboxamide and 2-substituted 4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide compounds using MDS vlife science QSAR plus module by using. Multiple Linear Regression (MLR), Principal Component Regression (PCR) and Partial Least Squares (PLS) Regression methods. Among these, MLR method has shown a very promising result as compared to other two methods and a QSAR model was generated by a training set of 28 molecules with correlation coefficient (r2) of0. 8319, significant cross validated correlation coefficient (q2) of 0.7913 and F test of 43.1480. In the selected descriptors, estate contribution, SsNH2E-index, SdOE-index, T_T_N_6 and T_C_N_7 descriptors were the most important descriptors in predicting antitubercular inhibitory activity.

Anti-tubercular activity;; Mycobacterium tuberculosis; Thiophene carboxamide derivbative; Multiple Linear Regression (MLR); Principal Component Regression (PCR); Partial Least Squares (PLS)

"2D-QSAR STUDY OF SUBSTITUTED THIOPHENE CARBOXAMIDE DERIVATIVES:AN APPROACH TO DESIGNANTI-TUBERCULAR AGENT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 7, page no.f560-f566, July-2022, Available :http://www.jetir.org/papers/JETIR2207571.pdf

"2D-QSAR STUDY OF SUBSTITUTED THIOPHENE CARBOXAMIDE DERIVATIVES:AN APPROACH TO DESIGNANTI-TUBERCULAR AGENT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 7, page no. ppf560-f566, July-2022, Available at : http://www.jetir.org/papers/JETIR2207571.pdf