• Mr. Rajeev Kumar
• Mr. Yograj Mahajan
• 3Mr. Harish Kumar Singh
• Dr. Prabhakar Budholiya

The main objective of the present research work was to develop a bilayer tablet of Lansoprazole and Metoclopramide hydrochloride and in separate layers to avoid incompatibility and thus to maximize the efficacy of both drugs in combination for the effective treatment to prevent and treat stomach ulcers. Lansoprazole and Metoclopramide hydrochloride were formulated as immediate and sustained release layers respectively. In vitro dissolution kinetic studies of an optimized in both layer and bilayer tablet forms show good linearity of regression coefficient Lansoprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough.. In our present research, we have selected the Lansoprazole active ingredient for study because it has treat stomach ulcers. In the present investigation we combine Lansoprazole and Metoclopramide hydrochloride as a formulated bilayer tablet to more effeteness of Lansoprazole.

Lansoprazole, Metoclopramide, Bilayer tablet, Stomach ulcers

"FORMULATION AND EVALUATION OF METOCLOPRAMIDE AND LANSOPRAZOLE BILAYER TABLETS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 7, page no.f748-f767, July-2022, Available :http://www.jetir.org/papers/JETIR2207590.pdf

"FORMULATION AND EVALUATION OF METOCLOPRAMIDE AND LANSOPRAZOLE BILAYER TABLETS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 7, page no. ppf748-f767, July-2022, Available at : http://www.jetir.org/papers/JETIR2207590.pdf