• Dr.Sruthi.N.V
• Dr,Swapna Bhat
• Mr. Sudhakar Bhat

The aim of this study was to investigate the acute toxicity of Coldenia procumbens Linn kashaya using Wistar albino rats. Acute toxicity study was performed using OECD guidelines 425,a dose of (175mg/kg, 550mg/kg, or 2000mg/kg) body weight administered orally to rats. In this study daily for 14 days animals were observed for toxic symptoms and mortality. The careful cage side observation was done without disturbing the animal attention and at the end of the every hour the animal were individually exposed to open arena for recording the behavioral changes like increased or decreased motor activity , convulsions, straub’s reaction, muscle spasm, catatonia, spasticity, ophisthotonus , hyperesthesia , muscle relaxation, anesthesia, arching and rolling, lacrimation, salivation , diarrhea, writhing , mode of respiration, changes in skin colour etc. exitus, CNS depression- hypo activity, passivity, relaxation, ataxia, narcosis, etc. and recorded in this study. The result of this acute toxicity study neither signs of toxicity nor mortality among the rats were observed of the experimental period. The overall this acute toxicity study indicates that Coldenia procumbens whole plant is non-toxic up to a dose of 2000mg/kg body weight, which could be considered a safe dose.

Coldenia procumbens , acute oral toxicity, OECD

"Acute oral toxicity study of Coldenia procumbens Linn whole plant Kashaya in Wistar albino rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 8, page no.a219-a223, August-2022, Available :http://www.jetir.org/papers/JETIR2208030.pdf

"Acute oral toxicity study of Coldenia procumbens Linn whole plant Kashaya in Wistar albino rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 8, page no. ppa219-a223, August-2022, Available at : http://www.jetir.org/papers/JETIR2208030.pdf