• Parth P. Patel
• Navin B. Patel
• Manesh S. Tople
• Vatsal M. Patel
• Dhanji P. Rajani

N-Mannich reaction has been carried out using 2-azaspiro[4.5]decan-3-one, formaldehyde, and various primary amines to give compounds 2a-i. All compounds are also formed using green roots and compared with the conventional method to ventilate the importance of the green synthesis method. 1H NMR, 13C NMR, IR, and Mass spectral analysis are used to evaluate the structures of final compounds. All synthesized moieties are subjected to antimicrobial and antitubercular activities. Compounds 2e and 2c exhibit significant antitubercular activities compared to reference drugs. In silico studies are also carried out such as ADMET studies and dynamic molecular studies. Binding affinities from docking analysis reveal the reason to be an active drug molecule by showing deep interaction details with proteins like Escherichia coli, Alkalihalobacillus halodurans C-125, Mycobacterium tuberculosis, and Mycobacterium tuberculosis H37Rv. In vitro outcomes are supported by these computational probes.

"GREEN SYNTHESIS OF GABAPENTIN DERIVATIVES: THEIR BIOLOGICAL EVALUATION AND IN SILICO STUDIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 8, page no.a298-a305, August-2022, Available :http://www.jetir.org/papers/JETIR2208042.pdf

"GREEN SYNTHESIS OF GABAPENTIN DERIVATIVES: THEIR BIOLOGICAL EVALUATION AND IN SILICO STUDIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 8, page no. ppa298-a305, August-2022, Available at : http://www.jetir.org/papers/JETIR2208042.pdf