• VED PRAKASH
• Dr. Yogita Tyagi
• Ms. Ankita

In this research triple-layer, buccal patch composed of immediate sustained and backing layer for delivering the medicament venlafaxine hydrochloride(show oral bioavailability 40%) for the treatment of depression by two actions HPMC E15 composed immediate layer provide instant action and release of the drug up to 1 hour then sustained release layer composed of guar gum provide sustained action up to next 7 hours. Triple-layer buccal patches for the delivery of atenolol using HPMC E15 and guar gum polymers in various proportions and combinations were fabricated by solvent casting technique. Various physicomechanical parameters like weight variation, thickness, folding endurance, drug content, moisture content, SEM study, moisture absorption, and various ex vivo mucoadhesion parameters like mucoadhesive strength, a force of adhesion, and bond strength were evaluated.

HPMC E15, Atenolol, mucoadhesion, triple layer

"PREPARATION AND EVALUATION OF TRIPLE LAYER DUAL RELEASE BUCCAL PATCHES OF ATENOLOL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 8, page no.c409-c414, August-2022, Available :http://www.jetir.org/papers/JETIR2208244.pdf

"PREPARATION AND EVALUATION OF TRIPLE LAYER DUAL RELEASE BUCCAL PATCHES OF ATENOLOL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 8, page no. ppc409-c414, August-2022, Available at : http://www.jetir.org/papers/JETIR2208244.pdf