• Amit kumar
• Mrs. Archana Rautela
• Ms Neha Tiwari

In this research a bi-layer tablets used to deliver the two different drugs having different release profile. These tablets are used to deliver the loading dose and maintenance dose of the same or different drug. These kind of tablets are mainly used in combination for modified release. Bi-layer tablets are used for bi-layer floating tablets in which one layer is floating layer another one is immediate release layer of the drug. Bilayer tablet is the novel technology for the development of controlled release formulation. Developing a combination of two or more active pharmaceutical ingredients in a single dosage form is known as a bilayer tablet. Bilayer tablet is more suitable for gradual release of two active ingredients in combination. Bi layered tablet technology helps in separating the two incompatible substances in which one layer is immediate release as loading dose and second layer is controlled/sustained release as maintenance dose. Two incompatible drugs can also be formulated into a bilayer tablet by adding an inert intermediate layer. For Glimepiride: 2 mg of Glimepiride to be prepare by Dry granulation method by using polymer in a different ratio. Drug and polymer will mix homogenously then lubricant and filler will added. All ingredients will mix and weigh accurately and compress in tablet punching machine in low compression force. For Metformin HCL: The tablet contains 250 mg of Metformin will prepare by wet Granulation method by using polymer in a different ratio. All ingredient should passed Through sieve mesh no: 40 separately. Drug and polymer shall be mix homogenously then Lubricant and filler shall added. All ingredients shall mix and weigh accurately and compress in a tablet punching machine.

THE FORMULATION AND EVALUATION OF BILYAER TABLET

"The Formulation And Evaluation Of Bilyaer Tablet", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 8, page no.c415-c423, August-2022, Available :http://www.jetir.org/papers/JETIR2208245.pdf

"The Formulation And Evaluation Of Bilyaer Tablet", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 8, page no. ppc415-c423, August-2022, Available at : http://www.jetir.org/papers/JETIR2208245.pdf