• RANAWARE PRATIK VINATAK
• VITTHAL J. CHAWARE
• ASHISH T. THORAT
• VIVEKKUMAR K. REDASANI

Aim of the study : In this study, we evaluated and compared the effect of Gymnema sylvestre, Saxagliptin, Insulin and Alloherbal combination (Gymnema sylvestre & Saxagliptin) on hyperglycemia, plasma lipid profile, liver enzymes in Alloxan induced diabetes mellitus in rats. Method: The antidiabetic activity (along with other parameters) of Gymnema sylvestre (100mg/kg), Saxagliptin (25mg/kg), Insulin (Human Actrapid; 10U/kg), Alloherbal combination (Gymnema sylvestre; 100mg/kg & Saxagliptin; 25mg/kg) was investigated in alloxan induced diabetes in rats. These drugs were administered once a day, for 14 days and blood glucose levels were measured on 0, 7 and 14th day. At the end of treatment various biochemical estimations & histopathological examination of pancreas were also carried out. Result: The statistical data indicated, 14 Days oral administration all drugs included in study showed significant (P<0.05) decreased in blood glucose, total cholesterol, triglycerides, LDL; SGPT and SGOT level , along with significant increase in HDL; But not better than Alloherbal combination. Conclusion : Present research findings provide experimental evidence that the combination of allopathic hypoglycemic drug; Saxagliptin with hypoglycemic herbal drug; Gymnema sylvestre provides effective and rapid glycemic control on diabetes mellitus and it could be considered for further evaluation in clinical studies and drug development.

Gymnema sylvestre, Saxagliptin, Insulin, Alloxan, Alloherbal combination, Diabetes

"A Comparative Study on Antidiabetic Activity of Gymnema Sylvestre, Saxagliptin, Insulin and Alloherbal Combination in Alloxan Induced Diabetic Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 8, page no.e84-e101, August-2022, Available :http://www.jetir.org/papers/JETIR2208409.pdf

"A Comparative Study on Antidiabetic Activity of Gymnema Sylvestre, Saxagliptin, Insulin and Alloherbal Combination in Alloxan Induced Diabetic Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 8, page no. ppe84-e101, August-2022, Available at : http://www.jetir.org/papers/JETIR2208409.pdf