• Rajesh Pandey
• Surendra Singh

Spirulina is free-floating filamentous microalgae consumed as food and widely used as a nutraceutical food supplement worldwide. The nutritional value of Spirulina is well recognized with its unusually high protein and richness in vitamins, minerals, essential fatty acids, and other nutrients. Recently, great attention and extensive studies have been devoted to evaluating its therapeutic benefits on an array of diseased conditions including hypercholesterolemia, Preclinical studies with various animal models consistently demonstrate the hypolipidemic activity of Spirulina. Similarly, some plants have a hypocholesterolemic response which Ginger is well known for. In the present investigation Spirulina (microalga) and Ginger (plant) alone and in combinations were evaluated against the HFD-induced hypercholesterolemic rat. Experiments were conducted in classified eight groups as n=4. Hypercholesterol induced on 40 days HFD administration and treatment was done through prepared individual and Spirulina and Ginger extract combination. GSH, SOD, TBARS, and Catalase antioxidants were examined from collected blood samples.. Spirulina exhibited a maximum decline of lipid peroxidation among individual therapies and in combinations, Ginger and Spirulina showed (13.63%), (21.05%) recovery action of Reduced Glutathione (mg/ml.), in combination 16.74% increasing response was accounted. Ginger (27.78%), Spirulina (31.6%), and a combination of both showed a (22.37%) decline in the beneficial response of Thiobarbituric acid (μg/ml.). Likewise the SOD (unit/min/mg protein) level increases with Ginger (50%) and Spirulina (44.23%) and (18.75%) in combination. Catalase (μmol/min/mg protein) increased the recovery response of Ginger (23.23%), Spirulina (21.95%), and in combination was shown (31.38%). The finding of the experiment suggested a potential free radical scavenging response of Spirulina with a combination of Ginger against HFD-induced hypercholesterolemia through alone and in combination therapy.

Antioxidant enzymes, Spirulina, Ginger, HFD, Hypercholesterol, and combination therapy

"Individual and combined free radical scavenging response of Spirulina with combination of Ginger against HFD induced hypercholesterolemia", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 8, page no.e319-e336, August-2022, Available :http://www.jetir.org/papers/JETIR2208440.pdf

"Individual and combined free radical scavenging response of Spirulina with combination of Ginger against HFD induced hypercholesterolemia", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 8, page no. ppe319-e336, August-2022, Available at : http://www.jetir.org/papers/JETIR2208440.pdf