• Shivam M. Sable
• Janhavi Y. Burade
• Dr. Vivek V. Paithankar
• Mr. J. V. Vyas
• Dr. A. M. Wankhade

Abstract: Objective: Selective estrogen Receptor modulators (SERM) are the class of drugs with mixed estrogen agonist-antagonist effects and have been proposed to be next generation of alternatives to traditional oestrogen replacement therapy, ideal SERM would exert estrogen agonist in the bone and in brain while simultaneously acting as an antagonist in tissue such as breast and uterus. This experiment was planned to explore the outcome of comparative effects of various estrogen receptor modulator Tamoxifen against Alzheimer disease in Wister female rats. Materials and methods: Doses of Rivastigmine, Tamoxifen were selected based on literature survey, Alzheimer was induced by giving scopolamine 3 mg/kg (i.p). To assess the spatial memory and cognitive impairment in rats, behavioural models such as Morris Water Maze test are used. Result: 30 days prior administration of different estrogen Receptor Modulators (ERM) i.e. Tamoxifen to female rats successfully reversed the oxidative stress, in increased the level of GSH induced by scopolamine and decreased the nitric oxide and acetylcholinesterase activity also increased the oestrogen level in serum of female rats. These effects associated enhancement of performance in behavioural models such as Morri’s water maze and novel object recognition test. Conclusion: The present study stresses the neuroprotective potential of estrogen receptor modulators; this finding contribute to the improvement of treatment in neurodegenerative disorder of Alzheimer type

: Estrogen receptor modulators, Tamoxifen, Alzheimer, Scopolamine

"Role of tamoxifen in Alzheimer Disease against Female Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 8, page no.f355-f367, August-2022, Available :http://www.jetir.org/papers/JETIR2208535.pdf

"Role of tamoxifen in Alzheimer Disease against Female Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 8, page no. ppf355-f367, August-2022, Available at : http://www.jetir.org/papers/JETIR2208535.pdf