UGC Approved Journal no 63975

ISSN: 2349-5162 | ESTD Year : 2014
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Volume 9 Issue 9
September-2022
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2209121


Registration ID:
502286

Page Number

b150-b169

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Title

APPLICATION OF ACTINOMYCETES IN SECONDARY METABOLITES PRODUCTION: AN OVERVIEW

Abstract

The secondary metabolites isolated from microbes and exhibits either antimicrobial (antibacterial, antifungal and antiprotozoans), antitumor and/or antiviral activities, used to be called as antibiotics. Secondary metabolites are also known as bioactive metabolites which work against microbes. There are more than 70% of the antibiotics can be obtained from members of the Actinomycetes family and it has been suggested that a large number of Actinomycetes may still be unknown with a potential to produce antibiotics. The presence of Multidrug resistant bacteria (MDR) is also responsible for the research of novel antibiotics and novel microbes. Exhibiting various bioactivities, they provide valuable approved drugs in clinical use. Actinobacteria, which share the characteristics of both bacteria and fungi, are widely distributed in both terrestrial and aquatic ecosystems, mainly in soil. They are considered as the biotechnologically valuable bacteria that are exploited for its secondary metabolite production. Approximately, 10,000 bioactive metabolites are produced by Actinobacteria, which is 45% of all bioactive microbial metabolites discovered. Especially Streptomyces species produce industrially important microorganisms as they are a rich source of several useful bioactive natural products like biosurfactant, enzyme, bioherbicides, vitamins, pigments, bioremediation, phytohormone production, odor and flavor compounds production etc. with potential applications. Though it has various applications, some Actinobacteria have its own negative effect against plants, animals, and humans. In this survey, a large number of the actinomycetes inhabit natural substrates which have the capacity to inhibit the growth of bacteria and other microorganisms. The ability of these actinomycetes to exert an inhibiting effect upon microorganisms is highly specific. Antagonistic actinornycetes produce a variety of antibiotics that vary in chemical nature, in antimicrobial action, in toxicity to animals, and in their chemotherapeutic potentialities. The antibiotics that have, so far, been isolated from actinomycetes vary in the degree of purification include: actinomycctin, actinomyces lysozyme, actinomycin, micromonosporin, streptothricin, streptomycin, and mycetin. Some actinomycetes produce more than one antibiotic substance. Some antibiotics are produced by several different organisms.

Key Words

Secondary metabolites; Multidrug resistant bacteria (MDR); Actinobacteria; natural products; antibiotics.

Cite This Article

"APPLICATION OF ACTINOMYCETES IN SECONDARY METABOLITES PRODUCTION: AN OVERVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 9, page no.b150-b169, September-2022, Available :http://www.jetir.org/papers/JETIR2209121.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"APPLICATION OF ACTINOMYCETES IN SECONDARY METABOLITES PRODUCTION: AN OVERVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 9, page no. ppb150-b169, September-2022, Available at : http://www.jetir.org/papers/JETIR2209121.pdf

Publication Details

Published Paper ID: JETIR2209121
Registration ID: 502286
Published In: Volume 9 | Issue 9 | Year September-2022
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.31513
Page No: b150-b169
Country: Sambalpur, Odisha, India .
Area: Biological Science
ISSN Number: 2349-5162
Publisher: IJ Publication


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