• Ramdas Bhat
• Sujana V Mestha
• Sahana Nagesh
• Preeti Shanbhag
• Grinton Josvi Veigas

The present study was conducted to examine the anti-inflammatory activity of aqueous fruits extract of Malus sylvestris using suitable experimental models. Wister rats were divided into 5 groups of n=6 each using Aspirin (300 mg/kg, p.o) as the standard drug. The Aqueous extract of Malus sylvestris was given at three doses of 200 mg/kg, 400 mg/kg and 800 mg/kg p.o. in distilled water respectively. Prepared extract was administered orally once daily for 7 consecutive days one hour prior to the administration of 0.1ml carrageenan injection in sub-plantar region. The volume of the rat paw was measured at the end of 7th day. The present study reveals that the aqueous extract of Malus sylvestris at the doses of 400 mg/kg and 800 mg/kg significantly reduced the carrageenan induced paw edema (P<0.001) at 3hr and 6hr in a dose dependent manner as compared to the vehicle control. Whereas 200mg/kg does not show any significance with that of control. As a result of the foregoing findings, the aqueous extract of Malus sylvestris fruit was found to have considerable anti-inflammatory activity in the carrageenan induced paw edema but was unable to completely prevent the inflammation.

Aqueous extract of Malus sylvestris fruit (AEMS), Paw edema, Carrageenan, Inflammation, Aspirin.

"“An Investigation of Anti-Inflammatory Activity of Aqueous Extract of Malus Sylvestris Fruits in Experimental Animals”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 9, page no.c606-c610, September-2022, Available :http://www.jetir.org/papers/JETIR2209292.pdf

"“An Investigation of Anti-Inflammatory Activity of Aqueous Extract of Malus Sylvestris Fruits in Experimental Animals”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 9, page no. ppc606-c610, September-2022, Available at : http://www.jetir.org/papers/JETIR2209292.pdf