• A Swaroopa Rani
• V Ravinder Reddy
• Ashok Kumar
• B Ramakrishna
• M L M Das

Abstract: Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant defense against oxidative stress in the body. Oxidative stress has become widely viewed as an underlying condition in several diseases such as central nervous system disorders, cancer, cardiovascular conditions, ischemia-reperfusion disorders, and diabetes. Thus, natural, and synthetic antioxidants have been actively sought. SOD is a first line of defense against oxidative stress under physiological and pathological conditions. SOD supplementation may trigger the endogenous antioxidant machinery for the neutralization of free-radical excess. However, the applications of natural SODs have been severely limited by their structural instability and high cost. To overcome these limitations of natural SODs, several low molecular weight metal ion complexes are developed as SOD mimetics. This paper is aimed at a brief review of natural SODs and their applications. This paper also reviews briefly about different SOD mimetics and their applications.

Index Terms: Superoxide dismutase (SOD), SOD mimetics, reactive oxygen species, human diseases, metal cation, mechanism

"SUPEROXIDE DISMUTASES (SODs) AND SOD MIMETICS: AN UPDATED REVIEW ON THEIR STRUCTURE, MECHANISM AND ROLE IN HUMAN DISEASES AND INDUSTRIAL APPLICATIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 9, page no.e924-e929, September-2022, Available :http://www.jetir.org/papers/JETIR2209510.pdf

"SUPEROXIDE DISMUTASES (SODs) AND SOD MIMETICS: AN UPDATED REVIEW ON THEIR STRUCTURE, MECHANISM AND ROLE IN HUMAN DISEASES AND INDUSTRIAL APPLICATIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 9, page no. ppe924-e929, September-2022, Available at : http://www.jetir.org/papers/JETIR2209510.pdf