• Avinash Kumar Jha
• Chetan Kumar Dubey
• Yaruna Patidar
• M.K. Gupta
• Nitin Nama, Abhishek Nagar

Intranasal medicine delivery – which has been rehearsed for thousands of times, has been given a new parcel of life. It's a useful delivery system for medicines that are active in low boluses and show no minimum oral bioavailability similar as proteins and peptides. Nasal delivery is the logical choice for topical treatment of original conditions in the nose and paranasal sinuses similar as antipathetic and non-allergic rhinitis and sinusitis. The nose is also considered an seductive route for needle-free vaccination and for systemic medicine delivery, especially when rapid-fire immersion and effect are asked. In addition, nasal delivery may help address issues related to poor bioavailability, slow immersion, medicine declination, and adverse events in the gastrointestinal tract and avoids the first-pass metabolism in the liver. The convenience of administration and bettered patient compliance are important in the design of nasal medicine delivery system which remains the favored route of medicine delivery in malignancy of colorful disadvantages. Remedy through intranasal administration has been an accepted form of treatment in the Ayurvedic system of Indian Medicine. Nasal route is salutary for the medicines which are unstable on oral administration because they're significantly degraded in GIT or metabolized by first pass effect in liver. Nasal route is indispensable to parenteral remedy and also useful for long term remedy.

Parcel,Medicines,Bioavailability,Vaccination,Convenience,Ayurvedic System, First Pass, GIT.

"RECENT ADVANCEMENT IN NASAL DRUG DELIVERY SYSTEM: A CURRENT REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 10, page no.b609-b619, October-2022, Available :http://www.jetir.org/papers/JETIR2210186.pdf

"RECENT ADVANCEMENT IN NASAL DRUG DELIVERY SYSTEM: A CURRENT REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 10, page no. ppb609-b619, October-2022, Available at : http://www.jetir.org/papers/JETIR2210186.pdf