• Rakhi Dixit
• Eisha Ganju
• Bhaskar Gupta

Transfersomes are particularly optimized, ultradeformable (ultraflexible) lipid supramolecular aggregates, which are able to penetrate the mammalian skin intact. Transfersome is a type of carrier system which is capable of transdermal delivery of low as well as high molecular weight drugs. Transfersomes penetrate through the pores of stratum corneum which are smaller than its size and get into the underlying viable skin in intact form. Luliconazole an optically active imidazole antifungal agent with broadspectrum activity, appears to inhibit ergosterol synthesis of fungi by inhibiting the enzyme lanosterol 14 α-demethylase. Inhibition of this enzyme’s activity by lluliconazole results in decreased amounts of ergosterol, a constituent of fungal cell membranes. Especially, luliconazole inhibited growth of all filamentous fungi except zygomycetes at low concentration. In addition, luliconazole is the active R enantiomer of a chiral molecule. The drug entrapment in formulation – 3 is higher than the other formulations. The diffusion study of luliconazole transfersome gave extended release of the drug which suffices to decreased dose, lesser frequent dose of treatment and more patient compliance.

Antifungal agents, Transferosomal gel,

"FORMULATION AND EVALUATION OF TRANSFEROSOMAL GEL OF LULICONAZOLE AS AN ANTIFUNGAL AGENT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 10, page no.d59-d65, October-2022, Available :http://www.jetir.org/papers/JETIR2210318.pdf

"FORMULATION AND EVALUATION OF TRANSFEROSOMAL GEL OF LULICONAZOLE AS AN ANTIFUNGAL AGENT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 10, page no. ppd59-d65, October-2022, Available at : http://www.jetir.org/papers/JETIR2210318.pdf