• Aniket Gorakshnath Akolkar
• Sawale Kundan Madhukar
• Pranali Prakash Anmal
• Anuradha Karbhari Chavan
• Roshni Uttamrao Suryavanshi

Eye is the most vital organ of body.The usual ophthalmic dosage forms are accountfor 90% of currently accessible ophthalmic formulations.The smajor trouble encountered is quick precornel drug loss. There are significant efforts being made to develop innovative drug delivery systems for ophthalmic administration in order to increase the bioavailability of ophthalmic medications. Recent studies on ocular medication delivery devices are focused on Amalgamation of several drug delivery technologies, that includes to build up systems which is not only extend the contact time of the vehicle at the ocular surface, but which at the same time slow down the removal of the drug.There are numerous innovative dose forms, including collagen shield, in­situ gel,Liposomes, niosomes, dendrimers, ocular iontophoresis, ocular film, ocusert, nanosuspension, nanoparticulate system, etc.Due to significant tear fluid turnover and dynamics that cause quick drug removal from the eyes, conventional administration techniques frequently produce subpar bioavailability and therapeutic response. Ophthalmic in situ gels were created as a result to solve the bioavailability issues.

In­situ gel, Novel ocular drug delivery system, gelation, Ion‐activated in­situ system, Sol to gel.

"IN­SITU GELLING OPHTHALMIC DRUG DELIVERY SYSTEM: A Review ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 10, page no.e324-e334, October-2022, Available :http://www.jetir.org/papers/JETIR2210445.pdf

"IN­SITU GELLING OPHTHALMIC DRUG DELIVERY SYSTEM: A Review ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 10, page no. ppe324-e334, October-2022, Available at : http://www.jetir.org/papers/JETIR2210445.pdf