• Jeffri Syaputra
• Sarma N Lumbanraja
• Fidel Ganis Siregar
• Hotma Partogi Pasaribu
• Ichwanul Adenin

Background: Metabolic syndrome prevalence increases significantly after menopause, this is mainly due to hormone replacement therapy and is associated with diabetes incidence as reflected by HbA1c levels. Currently, especially in Asia, isoflavones are proving to be promising alternative therapies replace hormone therapy for symptoms in menopausal women. Objective: This research aims to determine effect of soy isoflavone administration on HbA1c levels in postmenopausal women Methods: This research is a true experimental study with pre-post test randomized between-group design at Sari Mutiara Diski Pratama Clinic in July 2020–December 2020. Menopausal women aged 45-65 years who have met inclusion criteria were classified into 3 groups according to intervention given, namely placebo, estradiol valerate and isoflavone. Analysis of pre-posttest data in each group was analyzed by using T-paired test if data was normally distributed and Wilcoxon test if data were not normally distributed. Results: The mean sample age in estradiol valerate group was the oldest, followed by soy isoflavone and control group (54.7 ± 2.75 years; 52.5 ± 1.51 years; 52.4 ± 2.01 years). The highest level of HbA1c before intervention was found in Soy Isoflavone group (6,30). However, after intervention, the highest HbA1c levels were found in estradiol group (5,11) and lowest in soy isoflavone group (4,85). Conclusion: The difference in HbA1c levels before and after the intervention was found to be significant in after administration of either 50 mg soy isoflavone and estradiol valerate.

menopause, estrogen replacement therapy, isoflavone, estradiol valerate

"EFFECT OF SOY ISOFLAVONE ADMINISTRATION ON HBA1C LEVELS IN MENOPAUSE WOMEN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 10, page no.e397-e402, October-2022, Available :http://www.jetir.org/papers/JETIR2210458.pdf

"EFFECT OF SOY ISOFLAVONE ADMINISTRATION ON HBA1C LEVELS IN MENOPAUSE WOMEN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 10, page no. ppe397-e402, October-2022, Available at : http://www.jetir.org/papers/JETIR2210458.pdf