• Eli S
• Akune JI
• Azeez MO ,Aloku AA
• Okeji NAE
• Okagua KE , Ohwonda G, Nonye-Enyindah E, Kua P, Nnoka VE, Emeghara, Nnadi NO

Background: Untreated dental caries in permanent teeth is the most common health condition according to the Global Burden of Disease 2017. More than 530 million children suffer from dental caries of primary teeth while 2.3 billion people suffer from caries of permanent teeth. Caries in the primary dentition is one of the main risk factors for caries in the permanent dentition. Preventing the development of the first caries lesion is fundamental not only to long term health and well being but to reducing the burden of disease on individuals, families and the community. Described as the developmental origins of health and disease (DOHAD), events from the prenatal period are increasingly recognized as having a significant impact on later health outcomes. Developmental defects of enamel including enamel hypoplasia (EH), hypomineralised second primary molars and molar-incisor hypomineralisation arise as a result of events in pregnancy and early life and have been shown to be major risk factors for caries. As early as 1936, Stein reported that 5 out of 12 prematurely born children had enamel hypoplasia. Via and Churchill, 1959, attributed the cause of EH to maternal preeclampsia while Seow (1984b, 1987) proposed that decreased mineral stores (hypocalcemia) which may affect mineralization of dental tissues directly is the likely mechanism.

Assessment, biomarkers, prediction, prevention, pre-eclampsia, birth defect.

"PRELIMINARY ASSESSMENT OF CRITICAL BIOMARKERS FOR THE PREDICTION, PREVENTION AND MANAGEMENT OF PREECLAMPSIA AND DEVELOPMENTAL DENTAL DEFECTS – RESEARCH IN PERSPECTIVE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 11, page no.b288-b298, November-2022, Available :http://www.jetir.org/papers/JETIR2211155.pdf

"PRELIMINARY ASSESSMENT OF CRITICAL BIOMARKERS FOR THE PREDICTION, PREVENTION AND MANAGEMENT OF PREECLAMPSIA AND DEVELOPMENTAL DENTAL DEFECTS – RESEARCH IN PERSPECTIVE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 11, page no. ppb288-b298, November-2022, Available at : http://www.jetir.org/papers/JETIR2211155.pdf