• SIMI GEORGE
• VEENA R

ABSTRACT Cinnamon has been one of the most widely used spices for thousands of years, having a wide range of culinary applications. Immunomodulatory herbal medication has grown increasingly popular. The exact immunomodulatory action of this species, however, has yet to be determined. The study's goals were to assess the immunomodulatory effects of an ethanolic extract of Cinnamomum malabatrum on cell-mediated and humoral immunity, as well as to assess its efficacy by gene expression methods using RT-PCR technique. The haemagglutination test was performed to determine humoral immune response and delayed type hypersensitivity test is used to measure cell mediated immunity response with Levamisole (50mg/kg/day, p.o.) serving as a positive standard and cyclophosphamide serving as a negative standard. NF-ĸB expression from RT-PCR analysis was used to assess the extract's exvivo effects. Cinnamomum malabatrum ethanolic extract elicited a considerable increase in humoral immune and cell mediated immune response response. Exvivo studies revealed that the intensity of the band formed by the extract-treated group was higher than that of the control and cyclophosphamide groups. It may be concluded from the results of invivo and exvivo tests employing the ethanolic extract that the ethanolic extract of Cinnamomum malabatrum has a considerable immunomodulatory effect on experimental animals, which can be related to the plant extract's terpenoid and flavonoid content.

Cinnamomum malabatrum, immunomodulatory, Levamisole, Cyclophosphamide, Delayed type hypersensitivity, Nf -kB.

"IN VIVO AND EX VIVO STUDIES OF THE IMMUNOMODULATORY EFFECT OF CINNAMOMUM MALABATRUM ON FEMALE WISTAR RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 11, page no.c172-c183, November-2022, Available :http://www.jetir.org/papers/JETIR2211216.pdf

"IN VIVO AND EX VIVO STUDIES OF THE IMMUNOMODULATORY EFFECT OF CINNAMOMUM MALABATRUM ON FEMALE WISTAR RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 11, page no. ppc172-c183, November-2022, Available at : http://www.jetir.org/papers/JETIR2211216.pdf