• Shiv Kumar
• Kaushalya Bains
• Dr. Ram Babu
• Dr. Sakshi

The aim of this study was to develop a novel Nifedipine containing nanosuspension loaded fast dissolving film to improve the solubility, dissolution and onset action of the nifedipine drug. The nanosuspension of the nifedipine drug was prepared using media milling technique. The percentage of drug released at 30 minutes for each of the 13 batches' dependent variables showed wide variances, ranging from 58.14% to 97.99%, demonstrating a strong influence from the independent factors (X1 and X2) on the chosen answers. 3D response graph indicated increase in the percentage of drug release at 30 minutes with increases in the concentration of the stabilizer and milling agent. The developed nanosuspensions formulation NS14 was discovered to have average sizes of 299.8 nm, a polydispersity of 0.169. Optimized nanosuspension NS14 containing formulation was incorporated in the fast-dissolving film prepared using the film casting method. in vitro drug release profiles of nifedipine nanosuspension incorporating fast dissolving film and pure drug, it was found that the NS14F6 released roughly 98.18±0.68 more nifedipine in 8 minutes than the market preparation did, at 33.29±0.14%.

Nano Suspension, Fast Dissolving Film, Optimization, Formulation, Nifedipine

"COMPREHENSIVE RESEARCH ON NANOSUSPENSION", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 11, page no.c350-c368, November-2022, Available :http://www.jetir.org/papers/JETIR2211238.pdf

"COMPREHENSIVE RESEARCH ON NANOSUSPENSION", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 11, page no. ppc350-c368, November-2022, Available at : http://www.jetir.org/papers/JETIR2211238.pdf