• Shivam Barange
• shiva singh
• shahjad ahmad
• sayed wasim ahmad
• sashikant kumar manjhi, Dr. Anjita singh Thakur, Dr. Jagdish Chandra Rathi, Rahul sharma

The present study of Niosomes are one of the promising drug carriers that have a bilayer structure and are formed by self-association of nonionic surfactants and cholesterol in an aqueous phase. Niosomes are biodegradable, biocompatible, and nonimmunogenic. They have long shelf life, exhibit high stability, and enable the delivery of drug at target site in a controlled and/or sustained manner . the results revealed that the by optimization we can get better result in the release pattern of the drug. The present study demonstrated the successful preparation of Paracetamol niosomes and their evaluation. Formulation NSF-6 showed high entrapment efficiency (96.07%±0.35), particle size (4.22±0.47µm) and drug release (87.21%) over 80 h. Hence it was considered to be good niosomal formulation with greater bioavailability.

Matrix, Erosion, Evaluation, Sustained, Diffusion

"PREPARATION AND OPTIMIZATION OF PARACETAMOL LOADED NIOSOMES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 11, page no.d452-d464, November-2022, Available :http://www.jetir.org/papers/JETIR2211362.pdf

"PREPARATION AND OPTIMIZATION OF PARACETAMOL LOADED NIOSOMES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 11, page no. ppd452-d464, November-2022, Available at : http://www.jetir.org/papers/JETIR2211362.pdf